2ba2 | pdb_00002ba2

Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae

spinqualitylabelsall models 2ba2, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ba2 is a 3 chain structure with sequence from "filterable_agent_of_primary_atypical_pneumonia"_eaton_et_al._1944 "filterable agent of primary atypical pneumonia" eaton et al. 1944. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed We have determined the crystal structure of the DUF16 domain of unknown function encoded by the gene MPN010 of Mycoplasma pneumoniae at 1.8 A resolution. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils. The shorter one consists of 11 highly conserved residues. The sequence comprises noncanonical heptad repeats that induce a right-handed coiled-coil structure. The longer one is composed of approximately nine heptad repeats. In this coiled-coil structure, there are three distinguishable regions that confer unique structural properties compared with other known homotrimeric coiled-coils. The first part, containing one stutter, is an unusual phenylalanine-rich region that is not found in any other coiled-coil structures. The second part is a highly conserved glutamine-rich region, frequently found in other trimeric coiled-coil structures. The last part is composed of prototype heptad repeats. The phylogenetic analysis of the DUF16 family together with a secondary structure prediction shows that the DUF16 family can be classified into five subclasses according to N-terminal sequences. Based on the structural comparison with other coiled-coil structures, a probable molecular function of the DUF16 family is discussed. Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae.,Shin DH, Kim JS, Yokota H, Kim R, Kim SH Protein Sci. 2006 Apr;15(4):921-8. Epub 2006 Mar 7. PMID:16522803 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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