2bj6 | pdb_00002bj6

Crystal Structure of a decameric HNA-RNA hybrid

spinqualitylabelsall models 2bj6, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2bj6 is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 NonStd Res: 6HA, 6HC, 6HG, 6HT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids. Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.,Maier T, Przylas I, Strater N, Herdewijn P, Saenger W J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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