3aqj | pdb_00003aqj

Crystal Structure of a C-terminal domain of the bacteriophage P2 tail spike protein, gpV

spinqualitylabelsall models 3aqj, resolution 1.27Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3aqj is a 6 chain structure with sequence from Bpp2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, CL, FE2 Gene: V (BPP2) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [VPV_BPP2] Forms the small spike at the tip of the tail. Publication Abstract from PubMed The adsorption and infection of bacteriophage P2 is mediated by tail fibres and tail spikes. The tail spikes on the tail baseplate are used to irreversibly adsorb to the host cells. Recently, a P2 phage tail-spike protein, gpV, was purified and it was shown that a C-terminal domain, Ser87-Leu211, is sufficient for the binding of gpV to host Escherichia coli membranes [Kageyama et al. (2009), Biochemistry, 48, 10129-10135]. In this paper, the crystal structure of the C-terminal domain of P2 gpV is reported. The structure is a triangular pyramid and looks like a spearhead composed of an intertwined beta-sheet, a triple beta-helix and a metal-binding region containing iron, calcium and chloride ions. The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure.,Yamashita E, Nakagawa A, Takahashi J, Tsunoda K, Yamada S, Takeda S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):837-41., Epub 2011 Jul 13. PMID:21821878 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Sandbox 3001 Spike protein

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