3b29 | pdb_00003b29

Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside

spinqualitylabelsall models 3b29, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3b29 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GSH, LSM, SO4 Related: 2pno, 3pcv Gene: LTC4S (HUMAN) Activity: Leukotriene-C(4) synthase, with EC number 4.4.1.20 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Function [LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Publication Abstract from PubMed Dodecyl-beta-D-selenomaltoside (SeDDM) is a seleno-detergent with a beta-glycosidic seleno-ether in place of the ether moiety in dodecyl-beta-D-maltoside. Seleno-detergents are candidates for heavy-atom agents in experimental phasing of membrane proteins in protein crystallography. Crystals of a nuclear membrane-embedded enzyme, leukotriene C(4) synthase (LTC(4)S), in complex with SeDDM were prepared and a multiwavelength anomalous diffraction (MAD) experiment was performed. The SeDDM in the LTC(4)S crystal exhibited sufficient anomalous diffraction for determination of the structure using MAD phasing. Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside.,Saino H, Ago H, Ukita Y, Miyano M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1666-73., Epub 2011 Nov 29. PMID:22139193 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Leukotriene C4 synthase

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