3cwf | pdb_00003cwf

Crystal structure of PAS domain of two-component sensor histidine kinase

spinqualitylabelsall models 3cwf, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3cwf is a 2 chain structure with sequence from Bacsu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, EPE Gene: phoR, BSU29100 (BACSU) Activity: Histidine kinase, with EC number 2.7.13.3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Function [PHOR_BACSU] Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. Publication Abstract from PubMed We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain. Extracytoplasmic PAS-like domains are common in signal transduction proteins.,Chang C, Tesar C, Gu M, Babnigg G, Joachimiak A, Pokkuluri PR, Szurmant H, Schiffer M J Bacteriol. 2010 Feb;192(4):1156-9. Epub 2009 Dec 11. PMID:20008068 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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