RING box protein

spinqualitylabelsall models Human RING finger protein 1 (green) complex with cullin-1 (grey), glomulin (magenta) and Zn+2 ions (grey) (PDB code 4f52) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D RING box protein (RBX) makes a heterodimer with cullin. The heterodimer is essential for the protein ubiquitination process. RBX1 is a component of the SCF (Skp1-cullin-F box protein) E3 ubiquitin ligase complex. RBX contains a RING-type zinc finger domain. The RING domain is 40 to 60 residues long and binds two Zn atoms. It is involved in protein-protein interaction. Relevance Overexpression of RBX1 contributes to tumor progression and poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. RBX1 and RBX2 are overexpressed in multiple human cancer tissues and required for the growth and survival of cancer cells.

3D Structures of RING box protein

Ring box protein 3D structures

Updated on 03-March-2022

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• Ring box protein 1 or E3 ubiquitin-protein ligase RBX1
  • 2lgv – hRBX1 residues 12-108 (mutant) – human - NMR
    
  • 1ldj – hRBX1 + hCullin-1
    
  • 3rtr – hRBX1 + hCullin-1 residues 411-766 (mutant)
    
  • 1ldk – hRBX1 + hCullin-1 + cyclin A/Cdk2-asociated protein + Skp2-like protein
    
  • 1u6g – hRBX1 + hCullin-1 + TIP120 protein
    
  • 4f52 – hRBX1 + hCullin-1 residues 411-690 (mutant) + glomulin
    
  • 4p5o – hRBX1 + hCullin-1 residues 411-776 + Dcn1-like protein + NEDD8-conjugating enzyme Ubc12 + NEDD8-conjugating enzyme Ubc12 + NEDD8
    
  • 7b5s – hRBX1 + cullin-1 + ARIH1 – Cryo EM
    
  • 7b5n – hRBX1 + cullin-1 + UBE2L3 + ubiquitin + ARIH1 – Cryo EM
    
  • 6ttu – hRBX1 + cullin-1 + UBE2D2 + NEDD8 + SIII – Cryo EM
    
  • 7b5m – hRBX1 + cullin-1 + CKS-1 + cyclin-dependent kinase inhibitor + S-phase kinase-associated protein + ubiquitin + ARIH1 – Cryo EM
    
  • 7b5l – hRBX1 in SCF-RBR E3-E3 super assembly – Cryo EM
    
  • 5n4w – hRBX1 + hCullin-2 + VHL + elongin B + elongin C
    
  • 2hye – hRBX1 + hCullin-4A + DNA damage-binding protein 1 + nonstructural protein
    
  • 4a0k – hRBX1 + hCullin-4A + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA
    
  • 7okq – hRBX1 + cullin-4A + DDB1 + DCAF1 – Cryo EM
    
  • 3dpl – hRBX1 + hCullin-5 residues 401-780 (mutant)
    
  • 3dqv – hRBX1 + hCullin-5 residues 401-780 (mutant) + NEDD8
    
  • 4a0c – hRBX1 + hCullin-4B residues 192-913 + Cullin-associated NEDD8-dissociated protein
    
  • 4a0l – hRBX1 + hCullin-4B + DNA damage-binding protein 1 + DNA damage-binding protein 2 + DNA
    
  • 6r6h – hRBX1 in signalosome – Cryo EM
    
• Ring box protein 2
  • 2ecl – hRBX2 RING domain - NMR
    
  • 6v9i – hRBX2 + cullin-5 – Cryo EM
    
  • 7oni – hRBX2 + cullin-5 + NEDD8 + ARIH2 – Cryo EM
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel