6a96 | pdb_00006a96

Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25

Loading... Status: waiting for Mol* initialization Structural highlights 6a96 is a 8 chain structure with sequence from Camelus glama and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ABU, BMA, MAN, NAG Gene: GABRB3 (HUMAN), GABRA5 (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [GBRB3_HUMAN] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry. Function [GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [GBRB3_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. See Also GABA receptor 3D structures

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