2uy1 | pdb_00002uy1

CRYSTAL STRUCTURE OF CSTF-77

spinqualitylabelsall models 2uy1, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2uy1 is a 2 chain structure with sequence from Enccn. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue. The structure of the CstF-77 homodimer provides insights into CstF assembly.,Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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