Sandbox 1711

Neurofibromin

spinqualitylabelsall models Closed conformation of Neurofibromin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D --- [1] Figure_1 Structure Neurofibromin is a homodimer with two identical chains (depicted as lime and cyan). Conformation: Closed In the overall closed closed neurofibromin and inactive conformation of the neurofibromin protein, both sets of the GRD and Sec14-PH domains are rotated in a way that they are inaccessible and inactive. The closed conformation is much more tightly compacted and there is no room for association with the Ras protein. vertical view Domains GRD domain Key Players R1276

Student Contributors

• Hannah Luchinski