7ro3 | pdb_00007ro3

Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 2

spinqualitylabelsall models 7ro3, resolution 4.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7ro3 is a 1 chain structure with sequence from Sulfolobus monocaudavirus smv1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Spindle- or lemon-shaped viruses infect archaea in diverse environments. Due to the highly pleomorphic nature of these virions, which can be found with cylindrical tails emanating from the spindle-shaped body, structural studies of these capsids have been challenging. We have determined the atomic structure of the capsid of Sulfolobus monocaudavirus 1, a virus that infects hosts living in nearly boiling acid. A highly hydrophobic protein, likely integrated into the host membrane before the virions assemble, forms 7 strands that slide past each other in both the tails and the spindle body. We observe the discrete steps that occur as the tail tubes expand, and these are due to highly conserved quasiequivalent interactions with neighboring subunits maintained despite significant diameter changes. Our results show how helical assemblies can vary their diameters, becoming nearly spherical to package a larger genome and suggest how all spindle-shaped viruses have evolved from archaeal rod-like viruses. Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.,Wang F, Cvirkaite-Krupovic V, Vos M, Beltran LC, Kreutzberger MAB, Winter JM, Su Z, Liu J, Schouten S, Krupovic M, Egelman EH Cell. 2022 Mar 17. pii: S0092-8674(22)00199-4. doi: 10.1016/j.cell.2022.02.019. PMID:35325592 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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