Terminase

spinqualitylabelsall models Terminase large subunit complex with ATP (PDB code 4ife) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Terminase (Ter) is a key component of the DNA packaging machine found in bacteriophages and herpesviruses. The Ter complex is comprised of a small Ter subunit which is a recognition subunit and a large Ter subunit which is an endonuclease/translocase subunit . The nuclease activity of the large Ter subunit is stimulated by ATP. The tripartite terminase complex of herpesvirus which contains 3 subunits (TRM1, TRM2 and TRM3), is found in the cytoplasm of infected cells and uses the cell's import machinery to enter the nucleus. TRM3 has RNase H-like activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genome. Structural highlights The large subunit of Ter is composed of an N-terminal ATPase domain, a linker region and a C-terminal nuclease domain. ATP binds to the protein in a groove between the ATPase domain and the linker region. 3D Structures of terminase Terminase 3D Structures

3D Structures of terminase

Updated on 19-April-2022

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• Terminase small subunit
  • Terminase 3D Structures , 3n4q – HvTer nuclease domain – Herpesvirus
    
  • 6ey7 – HvTer nuclease domain + inhibitor
    
  • 3hef, 7lxs – Ter – Bacteriophage T7
    
  • 4zc3, 2cmp – Sf6Ter nuclease domain – Bacteriophage Sf6
    
  • 4dyc, 4dzj, 4dzp – Sf6Ter nuclease domain (mutant)
    
  • 3zqp, 3zqm, 3zqn, 3zqo – Sf6Ter oligomerization domain
    
  • 3zqq, 4dyq, 4dyr – Sf6Ter
    
  • 1j9i – Ter nuclease domain – Bacteriophage λ - NMR
    
  • 4xvn – G20cTer nuclease domain – Bacteriophage G20c
    
  • 3p9a – Ter – Bacteriophage P22
    
  • 6v1i – Ter – Thermus virus – Cryo EM
    
  • 6ejq – TpTer – Thermus phage
    
  • 7lw0 – Ter – E. coli virus λ
    
  • 6hn7 – Ter + RPPC
    
  • 7joq – Ter – Pseudomonas phage NV1
    
  • 6w7t – Ter – Pseudomonas phage PaP3
    
  • 7lwr – Ter – Enterobacteria phage P21
    
• Terminase large subunit
  • 4dkw – Ter nuclease domain – Bacteriophage P22
    
  • 4bij, 4bil – T7Ter – Bacteriophage T7 – Cryo EM
    
  • 4idh – T7Ter
    
  • 2wbn, 2wc9 – Ter nuclease domain – Bacteriophage Spp1
    
  • 3c6a, 3c6h – Ter nuclease domain – Bacteriophage Rb49
    
  • 5c10, 5c12 – Sf6Ter nuclease domain
    
  • 5c2d, 5c15 – Sf6Ter nuclease domain (mutant)
    
  • 5m1f, 5m1k, 5m1n, 5m1o, 5m1p, 5m1q – G20cTer
    
  • 5oe8, 5oee, 5oe9 – D6eTer – Bacteriophage D6e
    
  • 5tge – P74Ter nuclease domain – Thermus phage P74
    
  • 4zni, 4znk – P74Ter ATPase domain
    
  • 4znj – P74Ter ATPase domain (mutant)
    
  • 6z6d, 6z6e – Ter – E. coli virus H97
    
• Terminase large subunit complex
  • 4iee, 4ife – Sf6Ter + ATP
    
  • 4iei – Sf6Ter + ADP
    
  • 5c2f – Sf6Ter nuclease domain (mutant) + antifungal drug
    
  • 5oea – D6eTer + ATP
    
  • 5oeb – D6eTer + ADP
    
  • 6vi1, 6xmi – Ter + antibody – Salmonella phage P22
    
  • 4znl – P74Ter ATPase domain + ADP
    
  • 7ks4 – TpTer ATPase domain + ADP
    
• Tripartite terminase
  • 6m5s, 6m5r – HvTer TRM1+TRM2+TRM3 – Cryo EM
    
  • 6m5u, 6m5v – HvTer TRM1+TRM2+TRM3 + ADP – Cryo EM
    
  • 6m5t – HvTer TRM3 – Cryo EM
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman