3j0h | pdb_00003j0h

Fitting of the bacteriophage phiKZ gp29PR structure into the cryo-EM density map of the phiKZ extended tail sheath

Loading... Status: waiting for Mol* initialization Structural highlights 3j0h is a 6 chain structure with sequence from Pseudomonas phage phikz. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3spe, 3j0i, 3hxl, 3lml Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Bacteriophage phiKZ is a giant phage that infects Pseudomonas aeruginosa, a human pathogen. The phiKZ virion consists of a 1450 A diameter icosahedral head and a 2000 A-long contractile tail. The structure of the whole virus was previously reported, showing that its tail organization in the extended state is similar to the well-studied Myovirus bacteriophage T4 tail. The crystal structure of a tail sheath protein fragment of phiKZ was determined to 2.4 A resolution. Furthermore, crystal structures of two prophage tail sheath proteins were determined to 1.9 and 3.3 A resolution. Despite low sequence identity between these proteins, all of these structures have a similar fold. The crystal structure of the phiKZ tail sheath protein has been fitted into cryo-electron-microscopy reconstructions of the extended tail sheath and of a polysheath. The structural rearrangement of the phiKZ tail sheath contraction was found to be similar to that of phage T4. Structural conservation of the myoviridae phage tail sheath protein fold.,Aksyuk AA, Kurochkina LP, Fokine A, Forouhar F, Mesyanzhinov VV, Tong L, Rossmann MG Structure. 2011 Dec 7;19(12):1885-94. PMID:22153511 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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