3j1v | pdb_00003j1v

A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly

Loading... Status: waiting for Mol* initialization Structural highlights 3j1v is a 15 chain structure with sequence from "bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4g08, 4g1i, 3j1w, 3j1x Gene: invG, STM2898 ("Bacillus typhimurium" Loeffler 1892) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [INVG_SALTY] Involved in the invasion of the cells of the intestinal epithelium. Could be necessary for the export of invasion related determinants. Publication Abstract from PubMed Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly. Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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