Ricin: Structure and function

Ricin

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Found inside of the seeds of the castor oil plant and in castor beans, the cytotoxin, Ricin, is known to be one of Earth's most toxic proteins. Ricin was officially discovered in the year 1888 during the investigation of castor seed toxicity, which had been a mystery to scientists since their observations of its effects in the late nineteenth century. German scientist, Peter Hermann Stillmark, was able to extract this compound from the castor seed and purify it into the structure we see today. Originally thought to be used in aiding cancer patients, its highly toxic nature to humans deemed it too dangerous to use in a medical setting. Doctors and scientists have even worked together to pick apart the protein and use each chain in cancer therapy separately. On the other hand, it’s toxicity attracted the attention of criminals, military, and terrorists who came up with the idea of using it as a weapon in bio-terroristic attacks. or to the article describing Jmol to the rescue. Ricin Poisoning: Treatment Ricin’s effect on an organism's body can happen so suddenly and severely that the treatment of ricin poisoning is very variable. Scientists and doctors both recommend that those who may have consistent exposure to ricin and maybe at high risk of being poisoned receive vaccinations to prevent ricin from being able to come in contact with internal cells. It is also highly recommended that worksites that produce castor oil and have high levels of ricin circulating throughout solutions go through very extensive decontamination processes. If an individual does become poisoned, it is important that their water and blood levels are being monitored and maintained as they are given anti-ricin antibodies to protect the cells. This can extend survival time and even help the organism to fight off the ricin completely.

References

Audi J, Belson M, Patel M, Schier J, Osterloh J. Ricin Poisoning: A Comprehensive Review. JAMA. 2005;294(18):2342–2351. doi:10.1001/jama.294.18.2342

Etimad, L., Moshiri, M., & Hamid, F. (2019, June 6). Ricin: An ancient story for a timeless plant toxin. RBMB. Retrieved April 23, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628454/#sec2-toxins-11-00324title

Gal, Y., Mazor, O., Falach, R., Sapoznikov, A., Kronman, C., & Sabo, T. (2017). Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects. Toxins, 9(10). https://doi-org.proxy.library.maryville.edu/10.3390/toxins910031

Tumer, N. E. (2019). Introduction to the Toxins Special Issue “Ricin Toxins.” Toxins, 12(1). https://doi-org.proxy.library.maryville.edu/10.3390/toxins12010013/

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