Transaldolase
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Revision as of 07:55, 27 April 2022 by Michal Harel (talk | contribs)
FunctionTransaldolase (TAL) is part of the pentose phosphate pathway. It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate[1]. See also Lysine-cysteine NOS bonds. DiseaseTAL deficiency influences mitochondrial homeostasis, Ca+2 fluxing and apoptosis[2]. Structural highlightsTAL overall structure is of a TIM barrel (Alpha Helices, Beta Strands , Loops , Turns). The active site contains a Schiff-base-bound phosphosugar at Lys135[3]. Water molecules are shown as red spheres. Cl coordination site. 3D Structures of transaldolase
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3D Structures of transaldolase
Updated on 27-April-2022
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- Transaldolase
- Lysine-cysteine NOS bonds – TAL – human
- Transaldolase 3D structures, 2e1d – TAL (mutant) – mouse
- 3clm, 6zwf, 6zwh, 6zwj, 6zx4, 7b0l, 7odo, 7odp, 7odq –NgTAL – Neisseria gonorrhoeae
- 7bbw, 7bbx, 7oey - NgTAL (mutant)
- 3cwn, 1onr, 1ucw - EcTAL B – Escherichia coli
- 3kof, 1i2n, 1i2o, 1i2p, 1i2q, 1i2r, 4rz5, 4rz6 - EcTAL B (mutant)
- 3hjz – TAL B – Prochlorococcus marinus
- 3igx, 4e0c – FtTAL B – Francisella tularensis
- 3m16 – TAL – Oleispira Antarctica
- 3r8r – TAL – Bacillus subtilis
- 3r5e – TAL – Corynebacterium glutamicum
- 1vpx – TAL – Thermotoga maritima
- 1wx0 – TAL – Thermus thermophilus
- 6yre - TaTAL – Thermoplasma acidophilum
- Lysine-cysteine NOS bonds – TAL – human
- Transaldolase binary complexes
- 3tk7 - FtTAL B + fructose 6-phosphate
- 3te9 - FtTAL B (mutant) + fructose 6-phosphate
- 3tkf - FtTAL B (mutant) + seduheptulose 7-phosphate
- 3tno - FtTAL B + seduheptulose 7-phosphate
- 3upb - FtTAL B + arabinose 5-phosphate
- 4s2b - EcTAL B + tagatose 6-phosphate
- 4s2c, 4s1f - EcTAL B + fructose 6-phosphate
- 4rxf, 4rxg, 4rz4 - EcTAL B (mutant) + fructose 6-phosphate
- 4xz9 - TaTAL + glycerol 3-phosphate
- 6yr3 - TaTAL + fructose 6-phosphate
- 6yrh, 6yrm, 6yrt - TaTAL (mutant) + fructose 6-phosphate
- 3tk7 - FtTAL B + fructose 6-phosphate
References
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