1eqy | pdb_00001eqy
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COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1
Overview
The structure of the segment 1 domain of gelsolin, a protein that, fragments actin filaments in cells, is reported in complex with actin., Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in, a cleft between actin domains. On the actin filament model it binds, tangentially, disrupting only those contacts between adjacent subunits in, one helical strand. The segment 1 fold is general for all segments of the, gelsolin family because the conserved residues form the core of the, structure. It also provides a basis for understanding the origin of an, amyloidosis caused by a gelsolin variant.
Disease
Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]
About this Structure
1EQY is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus with CA and ATP as ligands. Full crystallographic information is available from OCA.
Reference
Structure of gelsolin segment 1-actin complex and the mechanism of filament severing., McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Nature. 1993 Aug 19;364(6439):685-92. PMID:8395021
Page seeded by OCA on Mon Nov 12 16:45:51 2007
