3jb4 | pdb_00003jb4

Structure of Ljungan virus: insight into picornavirus packaging

Loading... Status: waiting for Mol* initialization Structural highlights 3jb4 is a 3 chain structure with sequence from Ljungan virus 87-012. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Picornaviruses are responsible for a range of human and animal diseases, but how their RNA genome is packaged remains poorly understood. A particularly poorly studied group within this family are those that lack the internal coat protein, VP4. Here we report the atomic structure of one such virus, Ljungan virus, the type member of the genus Parechovirus B, which has been linked to diabetes and myocarditis in humans. The 3.78-A resolution cryo-electron microscopy structure shows remarkable features, including an extended VP1 C terminus, forming a major protuberance on the outer surface of the virus, and a basic motif at the N terminus of VP3, binding to which orders some 12% of the viral genome. This apparently charge-driven RNA attachment suggests that this branch of the picornaviruses uses a different mechanism of genome encapsidation, perhaps explored early in the evolution of picornaviruses. Structure of Ljungan virus provides insight into genome packaging of this picornavirus.,Zhu L, Wang X, Ren J, Porta C, Wenham H, Ekstrom JO, Panjwani A, Knowles NJ, Kotecha A, Siebert CA, Lindberg AM, Fry EE, Rao Z, Tuthill TJ, Stuart DI Nat Commun. 2015 Oct 8;6:8316. doi: 10.1038/ncomms9316. PMID:26446437 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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