3lfk | pdb_00003lfk

A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators

spinqualitylabelsall models 3lfk, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3lfk is a 4 chain structure with sequence from Thevo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CIT, SO4 Gene: TV0762, TVG0766549 (THEVO) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Several archaeal mechanosensitive (MS) channels have been reported, including one from Thermoplasma volcanium designated MscTV. Here, we report the crystal structure of MscTV at 1.6-A resolution. Unexpectedly, MscTV was found to be a water-soluble protein exhibiting a winged helix-turn-helix (wHTH) motif, which is the signature of the MarR (multiple antibiotic resistance regulator) family of transcriptional regulators. A cell-based osmotic downshock functional assay demonstrated that MscTV was unable to protect a knockout strain of Escherichia coli from hypoosmotic shock, further indicating that it does not function as a MS channel. We propose this protein be renamed MLPTv for MarR-like protein from T. volcanium. A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators.,Liu Z, Walton TA, Rees DC Protein Sci. 2010 Apr;19(4):808-14. PMID:20162616 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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