3nug | pdb_00003nug

Crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti

spinqualitylabelsall models 3nug, resolution 1.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3nug is a 4 chain structure with sequence from Atcc 700743. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACY, NAD Gene: mlr6807, pldh-t (ATCC 700743) Activity: Pyridoxal 4-dehydrogenase, with EC number 1.1.1.107 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PLDH_RHILO] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphate, 4-phthalaldehyde, 2-nitrobenzaldehyde, pyridine, formaldehyde, 2-carboxybenzaldehyde or sugars. Publication Abstract from PubMed Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme. The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti.,Chu HN, Kobayashi J, Mikami B, Yagi T Biosci Biotechnol Biochem. 2011;75(2):388-90. Epub 2011 Feb 7. PMID:21307574 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA