3onm | pdb_00003onm

Effector binding Domain of LysR-Type transcription factor RovM from Y. pseudotuberculosis

spinqualitylabelsall models 3onm, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3onm is a 2 chain structure with sequence from Yerp3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: lrhA, RovM, YpsIP31758_1452 (YERP3) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed In enteropathogenic Yersinia, the expression of several early-phase virulence factors such as invasin is tightly regulated in response to environmental cues. The responsible regulatory network is complex, involving several regulatory RNAs and proteins such as the LysR-type transcription regulator (LTTR) RovM. In this study, the crystal structure of the effector-binding domain (EBD) of RovM, the first LTTR protein described as being involved in virulence regulation, was determined at a resolution of 2.4 A. Size-exclusion chromatography and comparison with structures of full-length LTTRs show that RovM is most likely to adopt a tetrameric arrangement with two distant DNA-binding domains (DBDs), causing the DNA to bend around it. Additionally, a cavity was detected in RovM which could bind small inducer molecules. Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.,Quade N, Dieckmann M, Haffke M, Heroven AK, Dersch P, Heinz DW Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):81-90. Epub 2011, Jan 8. PMID:21245528 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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