3qc7 | pdb_00003qc7

The structure of bacteriophage phi29 head fibers has a supercoiled triple repeating helix-turn-helix motif

spinqualitylabelsall models 3qc7, resolution 1.52Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3qc7 is a 1 chain structure with sequence from Bpph2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: 8.5 (BPPH2) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The tailed bacteriophage 29 capsid is decorated with 55 fibers attached to quasi-3-fold symmetry positions. Each fiber is a homotrimer of gene product 8.5 (gp8.5) and consists of two major structural parts, a pseudohexagonal base and a protruding fibrous portion that is about 110 A in length. The crystal structure of the C-terminal fibrous portion (residues 112-280) has been determined to a resolution of 1.6 A. The structure is about 150 A long and shows three distinct structural domains designated as head, neck, and stem. The stem region is a unique three-stranded helix-turn-helix supercoil that has not previously been described. When fitted into a cryoelectron microscope reconstruction of the virus, the head structure corresponded to a disconnected density at the distal end of the fiber and the neck structure was located in weak density connecting it to the fiber. Thin section studies of Bacillus subtilis cells infected with fibered or fiberless 29 suggest that the fibers might enhance the attachment of the virions onto the host cell wall. Structure of bacteriophage {phi}29 head fibers has a supercoiled triple repeating helix-turn-helix motif.,Xiang Y, Rossmann MG Proc Natl Acad Sci U S A. 2011 Mar 7. PMID:21383126 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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