3qga | pdb_00003qga

3.0 A Model of Iron Containing Urease UreA2B2 from Helicobacter mustelae

spinqualitylabelsall models 3qga, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3qga is a 12 chain structure with sequence from Campylobacter mustelae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FE NonStd Res: FME, KCX Related: 3qgk Gene: HMU13020, ureA2 (Campylobacter mustelae), HMU13010, ureB2 (Campylobacter mustelae) Activity: Urease, with EC number 3.5.1.5 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Helicobacter mustelae, a gastric pathogen of ferrets, synthesizes a distinct iron-dependent urease in addition to its archetypical nickel-containing enzyme. The iron-urease is oxygen-labile, with the inactive protein exhibiting a methemerythrin-like electronic spectrum. Significantly, incubation of the oxidized protein with dithionite under anaerobic conditions leads to restoration of activity and bleaching of the spectrum. Structural analysis of the oxidized species reveals a dinuclear iron metallocenter bridged by a lysine carbamate, closely resembling the traditional nickel-urease active site. Although the iron-urease is less active than the nickel-enzyme, its activity allows H. mustelae to survive the carnivore's low-nickel gastric environment. Iron-containing urease in a pathogenic bacterium.,Carter EL, Tronrud DE, Taber SR, Karplus PA, Hausinger RP Proc Natl Acad Sci U S A. 2011 Jul 25. PMID:21788478 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Urease 3D structures

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