UMP/CMP kinase

spinqualitylabelsall models Structure of human UMP/CMP kinase complex with sulfate (PDB entry 1tev) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function UMP/CMP kinase (UCK) or uridylmonophosphate/cytidylmonophosphate kinase phosphorylates UMP, CMP and deoxy-CMP. Relevance Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK.

3D Structures of UMP/CMP kinase

Updated on 20-June-2022

1tev, 7e9v – UCK – human
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor

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