3rx8 | pdb_00003rx8

structure of AaCel9A in complex with cellobiose-like isofagomine

spinqualitylabelsall models 3rx8, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3rx8 is a 1 chain structure with sequence from Aliac. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 9MR, CA, MPD, ZN Related: 3gzk, 3h2w, 3h3k, 3rx5, 3rx7 Gene: celA (ALIAC) Activity: Cellulase, with EC number 3.2.1.4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Using structural insight, the binding mode of isofagomine-derived inhibitors with family GH9 glycosidases is achieved via the study of Alicyclobacillus acidocaldarius (AaCel9A) endoglucanase. In contrast to what was observed in the first report using these compounds with inverting glycosidases from family GH6, these inhibitors do not adopt a distorted conformation in the active site. A potential fortuitous binding of inhibitors of an inverting family GH9 beta-glycosidase derived from isofagomine.,Morera S, Vigouroux A, Stubbs KA Org Biomol Chem. 2011 Sep 7;9(17):5945-7. Epub 2011 Jul 25. PMID:21785782 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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