3san | pdb_00003san

Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir

spinqualitylabelsall models 3san, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3san is a 2 chain structure with sequence from I76a2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, GOL, NAG, ZMR Related: 3nss, 3sal Gene: NA (I76A2) Activity: Exo-alpha-sialidase, with EC number 3.2.1.18 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding. Influenza a virus n5 neuraminidase has an extended 150-cavity.,Wang M, Qi J, Liu Y, Vavricka CJ, Wu Y, Li Q, Gao GF J Virol. 2011 Aug;85(16):8431-5. Epub 2011 Jun 8. PMID:21653672 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Neuraminidase 3D structures

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