3sqf | pdb_00003sqf

Crystal structure of monomeric M-PMV retroviral protease

spinqualitylabelsall models 3sqf, resolution 1.63Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sqf is a 2 chain structure with sequence from Mpmv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1nso, 3hvp, 4hvp, 2rsp, 1yth, 4fiv, 2fmb, 3liy, 3nr6 Gene: pro, prt (MPMV) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs. Crystal structure of a monomeric retroviral protease solved by protein folding game players.,Khatib F, Dimaio F, Cooper S, Kazmierczyk M, Gilski M, Krzywda S, Zabranska H, Pichova I, Thompson J, Popovic Z, Jaskolski M, Baker D Nat Struct Mol Biol. 2011 Sep 18. doi: 10.1038/nsmb.2119. PMID:21926992 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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