3sub | pdb_00003sub

Crystal structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein

spinqualitylabelsall models 3sub, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sub is a 2 chain structure with sequence from Plaf7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4, ZN Gene: PFL2140c (PLAF7) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of the catalytic domain of the ADP ribosylation factor GTPase-activating protein (ARFGAP) from Plasmodium falciparum has been determined and refined to 2.4 A resolution. Multiwavength anomalous diffraction (MAD) data were collected utilizing the Zn(2+) ion bound at the zinc-finger domain and were used to solve the structure. The overall structure of the domain is similar to those of mammalian ARFGAPs. However, several amino-acid residues in the area where GAP interacts with ARF1 differ in P. falciparum ARFGAP. Moreover, a number of residues that form the dimer interface in the crystal structure are unique in P. falciparum ARFGAP. Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP).,Cook WJ, Senkovich O, Chattopadhyay D Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1339-44., Epub 2011 Oct 25. PMID:22102228 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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