4u6m | pdb_00004u6m

Crystal structure of DNA/RNA duplex obtained in the presence of Spermine

spinqualitylabelsall models 4u6m, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u6m is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: 5CM Related: 4u6k, 4u6l Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties. The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.,Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H Chem Commun (Camb). 2016 Feb 7;52(11):2354-7. doi: 10.1039/c5cc08300a. PMID:26731288 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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