3u1y | pdb_00003u1y

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

spinqualitylabelsall models 3u1y, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3u1y is a 2 chain structure with sequence from "bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 03I, ZN Gene: lpxC, envA, PA4406 ("Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Publication Abstract from PubMed In this paper we present the synthesis and SAR as well as selectivity, pharmacokinetic and infection model data for representative analogs of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a. Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections.,Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels J, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mulllins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello D, Warmus J, Wishka DG J Med Chem. 2011 Dec 18. PMID:22175825 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also UDP-3-O-acyl-N-acetylglucosamine deacetylase

Proteopedia Page Contributors and Editors (what is this?)

OCA