CAD protein

spinqualitylabelsall models Human CAD protein dihydroorotatase subunit containing modified Lys complex with dihydroorotate, formate and Zn+2 ions (PDB ID 6hg3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CAD protein is a trifunctional enzyme which contains dihydroorotase domain (DHO), aspartate transcarbamoylase domain (ATC) and carbamoylphosphate synthetase domain. The CAD protein catalyzes the first 3 of 6 reactions required for pyrimidine biosynthesis. Disease Deficiency in carbamoylphosphate synthetase leads to lack of urea and hyperammonemia Structural highlights The 3D structure of CAD protein dihydroorotase subunit complex with dihydroorotate shows the active site containing 2 Zn+2 ions and a flexible loop containing conserved Thr and Phe in a loop-out conformation. Water molecules are shown as red spheres. 3D structures of CAD protein CAD protein 3D structures

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Michal Harel, Alexander Berchansky