3ujm | pdb_00003ujm

Crystal structure of the NTF2-like domain of the Drosophila melanogaster Rasputin protein

spinqualitylabelsall models 3ujm, resolution 2.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ujm is a 2 chain structure with sequence from Drome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EPE Gene: rin, CG9412 (DROME) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7A resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a beta-sheet and three alpha-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site. Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.,Vognsen T, Kristensen O Biochem Biophys Res Commun. 2012 Mar 30;420(1):188-92. Epub 2012 Mar 3. PMID:22414690 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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