3ulf | pdb_00003ulf

The light state structure of the blue-light photoreceptor Aureochrome1 LOV

spinqualitylabelsall models 3ulf, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ulf is a 6 chain structure with sequence from Conferva frigida. The March 2015 RCSB PDB Molecule of the Month feature on Phototropin by David Goodsell is 10.2210/rcsb_pdb/mom_2015_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMN, PO4 Related: 3ue6 Gene: AUREO1 (Conferva frigida) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Aureochrome1, a signaling photoreceptor from a eukaryotic photosynthetic stramenopile, confers blue-light-regulated DNA binding on the organism. Its topology, in which a C-terminal LOV sensor domain is linked to an N-terminal DNA-binding bZIP effector domain, contrasts with the reverse sensor-effector topology in most other known LOV-photoreceptors. How, then, is signal transmitted in Aureochrome1? The dark- and light-state crystal structures of Aureochrome1 LOV domain (AuLOV) show that its helical N- and C-terminal flanking regions are packed against the external surface of the core beta sheet, opposite to the FMN chromophore on the internal surface. Light-induced conformational changes occur in the quaternary structure of the AuLOV dimer and in Phe298 of the Hbeta strand in the core. The properties of AuLOV extend the applicability of LOV domains as versatile design modules that permit fusion to effector domains via either the N- or C-termini to confer blue-light sensitivity. Crystal structures of Aureochrome1 LOV suggest new design strategies for optogenetics.,Mitra D, Yang X, Moffat K Structure. 2012 Apr 4;20(4):698-706. doi: 10.1016/j.str.2012.02.016. Epub 2012, Apr 3. PMID:22483116 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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