3uxw | pdb_00003uxw

Crystal Structures of an A-T-hook/DNA complex

spinqualitylabelsall models 3uxw, resolution 2.27Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3uxw is a 12 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: NH2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT-hook forms hydrogen bonds between main-chain NH groups and thymines in the minor groove, DNA is bent and the minor groove is widened. Crystal structure of a complex of DNA with one AT-hook of HMGA1.,Fonfria-Subiros E, Acosta-Reyes F, Saperas N, Pous J, Subirana JA, Campos JL PLoS One. 2012;7(5):e37120. Epub 2012 May 16. PMID:22615915 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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