1ftn | pdb_00001ftn
CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
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Overview
RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses, to extracellular signals. A 2.1 A resolution crystal structure of the, human RhoA-GDP complex shows unique stereochemistry in the switch I, region, which results in a novel mode of Mg2+ binding.
About this Structure
1FTN is a Single protein structure of sequence from Homo sapiens with MG and GDP as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of RhoA-GDP and its functional implications., Wei Y, Zhang Y, Derewenda U, Liu X, Minor W, Nakamoto RK, Somlyo AV, Somlyo AP, Derewenda ZS, Nat Struct Biol. 1997 Sep;4(9):699-703. PMID:9302995
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