3zq6 | pdb_00003zq6

ADP-ALF4 COMPLEX OF M. THERM. TRC40

spinqualitylabelsall models 3zq6, resolution 2.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zq6 is a 4 chain structure with sequence from "methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP, ALF, K, MG, ZN Activity: Arsenite-transporting ATPase, with EC number 3.6.3.16 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ARSA_METTH] Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity). Publication Abstract from PubMed Eukaryotic tail-anchored (TA) membrane proteins are inserted into the endoplasmic reticulum by a post-translational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP*AlF(4) (-) reveals characteristic features of eukaryotic TRC40 including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized. A conserved archaeal pathway for tail-anchored membrane protein insertion.,Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ Traffic. 2011 Jun 9. doi: 10.1111/j.1600-0854.2011.01229.x. PMID:21658170 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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