3zxc | pdb_00003zxc

E69 deletion mutant single insulin-like growth factor binding domain protein (SIBD-1) from Cupiennius salei

spinqualitylabelsall models 3zxc, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zxc is a 2 chain structure with sequence from American wandering spider. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACT Related: 3zxb Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SIBD1_CUPSA] Has a role in the innate immune system. Publication Abstract from PubMed Cupiennius salei single insulin-like growth factor binding domain protein (SIBD-1) is an 8.6 kDa Cys-, Pro-, and Gly-rich protein, discovered in the hemocytes of the Central American hunting spider Cupiennius salei. SIBD-1 exhibits high sequence similarity to the N-terminal domain of the insulin-like growth factor-binding protein superfamily and has been reported to play an important role in the spider's immune system. Here, the recombinant expression as well as the elucidation of the three dimensional structure of recombinant SIBD-1 and the characterization of the sugar moiety at Thr2 of native SIBD-1 is described in detail. Proteins 2012. (c) 2012 Wiley-Liss, Inc. Structural and Biochemical Characterization of Native and Recombinant Single Insulin-like Growth Factor-Binding Domain Protein (SIBD-1) from the Central American Hunting Spider Cupiennius salei (Ctenidae).,Trachsel C, Widmer C, Kampfer U, Buhr C, Baumann T, Kuhn-Nentwig L, Schurch S, Schaller J, Baumann U Proteins. 2012 May 24. doi: 10.1002/prot.24119. PMID:22622866 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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