4bc6 | pdb_00004bc6

Crystal structure of human serine threonine kinase-10 bound to novel Bosutinib Isoform 1, previously thought to be Bosutinib

spinqualitylabelsall models 4bc6, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4bc6 is a 1 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 3zz2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, XZN Related: 2j7t, 4aot Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry. Function [STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. See Also Serine/threonine protein kinase 3D structures

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