4bhk | pdb_00004bhk

Crystal Structure of Moss Leafy bound to DNA

spinqualitylabelsall models 4bhk, resolution 2.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4bhk is a 4 chain structure with sequence from Moss. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Transcription factors are key players in evolution. Changes affecting their function can yield novel life forms but also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which transcription factors acquire new activities. Here we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of LEAFY. We examined how these changes occurred at the structural level, and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions thereby allowing LEAFY to evolve new binding specificities while remaining a single copy gene. A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity.,Sayou C, Monniaux M, Nanao MH, Moyroud E, Brockington SF, Thevenon E, Chahtane H, Warthmann N, Melkonian M, Zhang Y, Wong GK, Weigel D, Parcy F, Dumas R Science. 2014 Jan 16. PMID:24436181 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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