7uut | pdb_00007uut

Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus mutants C295A and I86A provides better understanding of catalytic mechanism

spinqualitylabelsall models 7uut, resolution 1.89Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7uut is a 4 chain structure with sequence from Thermoanaerobacter pseudethanolicus. This structure supersedes the now removed PDB entry 7jnu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 2RP : (2R)-pentan-2-ol, FME : N-FORMYLMETHIONINE, K : POTASSIUM ION, NAP : NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZN : ZINC ION Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ADH_THEBR] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde. See Also Alcohol dehydrogenase 3D structures

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