4bwx | pdb_00004bwx

Structure of Neurospora crassa PAN3 pseudokinase mutant

spinqualitylabelsall models 4bwx, resolution 2.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4bwx is a 2 chain structure with sequence from Neurospora crassa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AGS, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PAN3_NEUCR] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity). See Also Ribonuclease 3D structures

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