4c2i | pdb_00004c2i

Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4

Loading... Status: waiting for Mol* initialization Structural highlights 4c2i is a 10 chain structure with sequence from Dengue virus 1 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG, PRD_900017 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [Q7TGE4_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] See Also Antibody 3D structures 3D structures of human antibody

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