7wsi | pdb_00007wsi

Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab

spinqualitylabelsall models 7wsi, resolution 3.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7wsi is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [NTCP_HUMAN] The disease is caused by variants affecting the gene represented in this entry. Function [NTCP_HUMAN] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799). (Microbial infection) Acts as a receptor for hepatitis B virus.

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