4dkz | pdb_00004dkz

Hairpin structure of a DNA dodecamer containing North-methanocarba-2'-deoxythymidine

spinqualitylabelsall models 4dkz, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4dkz is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 0KZ Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Incorporation of a bicyclo[3.1.0]hexane scaffold into the nucleoside sugar was devised to lock the embedded cyclopentane ring in conformations that mimic the furanose North and South sugar puckers. To analyze the effects of North-methanocarba-2'-deoxythymidine (N-MCdT) on the B-form DNA, we crystallized d(CGCGAA[mcTmcT]CGCG) with two N-MCdTs. Instead of a duplex, the 12mer forms a tetraloop hairpin, whereby loop N-MCdTs adopt the C4'-exo pucker (NE; P = 50 degrees ). Thus, the bicyclic framework does not limit the pucker to the anticipated C2'-exo range (NNW; P = -18 degrees ). The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.,Pallan PS, Marquez VE, Egli M Biochemistry. 2012 Mar 20. PMID:22409313 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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