7msy | pdb_00007msy

Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora

spinqualitylabelsall models 7msy, resolution 2.21Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7msy is a 1 chain structure with sequence from Micromonospora echinospora. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, CL, GOL, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8KND1_MICEC Publication Abstract from PubMed Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core. The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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