4f3v | pdb_00004f3v

Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis

spinqualitylabelsall models 4f3v, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4f3v is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SM, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ECCA1_MYCTU Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates. Publication Abstract from PubMed EccA1 is an important component of the type VII secretion system (T7SS) that is responsible for transport of virulence factors in pathogenic mycobacteria. EccA1 has an N-terminal domain of unknown function and a C-terminal AAA+ (ATPases associated with various cellular activities) domain. Here we report the crystal structure of the N-terminal domain of EccA1 from Mycobacterium tuberculosis, which shows an arrangement of six tetratricopeptide repeats that may mediate interactions of EccA1 with secreted substrates. Furthermore, the size and shape of the N-terminal domain suggest its orientation in the context of a hexamer model of full-length EccA1 . (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc. Crystal structure of the N-terminal domain of EccA ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.,Wagner JM, Evans TJ, Korotkov KV Proteins. 2013 Jul 2. doi: 10.1002/prot.24351. PMID:23818233 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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