1h6i | pdb_00001h6i
A REFINED STRUCTURE OF HUMAN AQUAPORIN 1
|
Overview
A refined structure of the human water channel aquaporin-1 is presented., The model rests on the high resolution X-ray structure of the homologous, bacterial glycerol transporter GlpF, electron crystallographic data at 3.8, A resolution and a multiple sequence alignment of the aquaporin, superfamily. The crystallographic R and free R values (36.7% and 37.8%), for the refined structure are significantly lower than for previous, models. Improved geometry and enhanced stability in molecular dynamics, simulations demonstrate a significant improvement of the aquaporin-1, structure. Comparison with previous aquaporin-1 models shows significant, differences, not only in the loop regions, but also in the core of the, water channel.
Disease
Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]
About this Structure
1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455
Page seeded by OCA on Mon Nov 12 17:13:23 2007
