4gw9 | pdb_00004gw9

Structure of a bacteriophytochrome and light-stimulated protomer swapping with a gene repressor

spinqualitylabelsall models 4gw9, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4gw9 is a 4 chain structure with sequence from Rhodopseudomonas palustris CGA009. This structure supersedes the now removed PDB entry 4eho. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BLA, MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B3Q7C0_RHOPT Publication Abstract from PubMed Phytochromes are photoreceptors in phototropic organisms that respond to light conditions by changing interactions between a response regulator and DNA. Bacterial phytochromes (BphPs) comprise an input photosensory core domain (PCD) and an output transducing domain (OTD). We report the structure of a BphP containing both PCD and the majority of its OTD, and demonstrate interaction with its cognate repressor. The OTD of RpBphP1, from Rhodopseudomonas palustris, is composed of a PAS/PAC domain and, to our knowledge, a hitherto unrecognized two-helix output sensor (HOS) domain. Unlike canonical BphPs, it does not transmit phosphorelay signals but forms a complex with the transcriptional repressor RpPpsR2 on photoconversion with far-red light. We show that HOS is essential for complex formation and that the anti-parallel dimer geometry is crucial in achieving HOS domain activation and protomer swapping under the control of light. These results provide insights into the steps taken by a two-component signaling system. Structure of a Bacteriophytochrome and Light-Stimulated Protomer Swapping with a Gene Repressor.,Bellini D, Papiz MZ Structure. 2012 Jul 10. PMID:22795083 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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