Structural highlights
Function
GST28_SCHHA Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.[1] GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.[2]
References
- ↑ Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:https://dx.doi.org/10.1021/bi034449r
- ↑ Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136 doi:https://dx.doi.org/10.1021/bi034449r
