8axp | pdb_00008axp

Neisseria gonorrhoeae peptidyl-tRNA hydrolase complexed with an XChem hit.

spinqualitylabelsall models 8axp, resolution 1.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8axp is a 2 chain structure with sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: O0J, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PTH_NEIG2 The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Publication Abstract from PubMed A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria. Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.,Hassell-Hart S, Speranzini E, Srikwanjai S, Hossack E, Roe SM, Fearon D, Akinbosede D, Hare S, Spencer J Org Lett. 2022 Nov 4;24(43):7924-7927. doi: 10.1021/acs.orglett.2c02996. Epub, 2022 Oct 20. PMID:36265082 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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