7y14 | pdb_00007y14

Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)

spinqualitylabelsall models 7y14, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7y14 is a 1 chain structure with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BAL, PLM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MRGRD_HUMAN May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).C562_ECOLX Electron-transport protein of unknown function.

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